Enghild Lab Enghild Lab Enghild Lab Enghild Lab

2017


1.
An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimers Disease Patients. Open publication in PubMed
Poulsen ET, Iannuzzi F, Rasmussen HF, Maier TJ, Enghild JJ, Jørgensen AL, Matrone C.
Front Mol Neurosci. 2017 Mar 15;10:59.


2.
Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels. Open publication in PubMed
Poulsen ET, Pedersen KW, Marzeda AM, Enghild JJ.
Biochemistry. 2017 Feb 14;56(6).


3.
Reactive Center Loop Insertion in α-1-Antitrypsin Captured by Accelerated Molecular Dynamics Simulation Open publication in PubMed
Andersen OJ, Risør MW, Poulsen EC, Nielsen NC, Miao Y, Enghild JJ, Schiøtt B.
Biochemistry. 2017 Jan 31;56(4).


4.
Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa Open publication in PubMed
Andersen KK, Vad BS, Scavenius C, Enghild JJ, Otzen DE.
Biochemistry. 2017 Jan 10;56(1).


5.
"Ant-egg" cataract revisited Open publication in PubMed
Clemmensen K, Enghild JJ, Ivarsen A, Riise R, Vorum H, Heegaard S.
Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1).


2016


1.
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. Open publication in PubMed
Lasica AM, Goulas T, Mizgalska D, Zhou X, de Diego I, Ksiazek M, Madej M, Guo Y, Guevara T, Nowak M, Potempa B, Goel A, Sztukowska M, Prabhakar AT, Bzowska M, Widziolek M, Thøgersen IB, Enghild JJ, Simonian M, Kulczyk AW, Nguyen KA, Potempa J, Gomis-Rüth FX.
Sci Rep. 2016 Nov 24;6:37708.


2.
Disulfide Bond Pattern of Transforming Growth Factor β-Induced Protein. Open publication in PubMed
Lukassen MV, Scavenius C, Thøgersen IB, Enghild JJ.
Biochemistry. 2016 Okt 4;55(39), 5610-5621.


3.
How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin. Open publication in PubMed
Malmos KG, Bjerring M, Jessen CM, Nielsen EH, Poulsen ET, Christiansen G, Vosegaard T, Skrydstrup T, Enghild JJ, Pedersen JS, Otzen DE.
J Biol Chem. 2016 Aug 5;291(32), 16849-62.


4.
Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation. Open publication in PubMed
Iversen MB, Gottfredsen RH, Larsen UG, Enghild JJ, Praetorius J, Borregaard N, Petersen SV.
Free Radic Biol Med. 2016 Aug;97, 478-88.


5.
SILAC-MS Based Characterization of LPS and Resveratrol Induced Changes in Adipocyte Proteomics - Resveratrol as Ameliorating Factor on LPS Induced Changes. Open publication in PubMed
Nøhr MK, Kroager TP, Sanggaard KW, Knudsen AD, Stensballe A, Enghild JJ, Ølholm J, Richelsen B, Pedersen SB.
PLoS One. 2016 Jul 20;11(7), e0159747.


6.
Dynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro. Open publication in PubMed
Miclăuş T, Beer C, Chevallier J, Scavenius C, Bochenkov VE, Enghild JJ, Sutherland DS.
Nat Commun. 2016 Jun 9;7,11770.


7.
Carbamylated LL-37 as a modulator of the immune response. Open publication in PubMed
Koro C, Hellvard A, Delaleu N, Binder V, Scavenius C, Bergum B, Główczyk I, Roberts HM, Chapple IL, Grant MM, Rapala-Kozik M, Klaga K, Enghild JJ, Potempa J, Mydel P.
Innate Immun. 2016 Apr;22(3), 218-29.


8.
Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T. Open publication in PubMed
Kulminskaya NV, Yoshimura Y, Runager K, Sørensen CS, Bjerring M, Andreasen M, Otzen DE, Enghild JJ, Nielsen NC, Mulder FA.
Biomol NMR Assign. 2016 Apr;10(1), 25-9.


9.
The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain. Open publication in PubMed
de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P, Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA, Enghild JJ, Thøgersen IB, Gao J, Kwan AH, Trewhella J, Dubin G, Gomis-Rüth FX, Nguyen KA, Potempa J.
Sci Rep. 2016 Mar 23;6, 23123.


10.
Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy. Open publication in PubMed
Allen EH, Courtney DG, Atkinson SD, Moore JE, Mairs L, Poulsen ET, Schiroli D, Maurizi E, Cole C, Hickerson RP, James J, Murgatroyd H, Smith FJ, MacEwen C, Enghild JJ, Nesbit MA, Leslie Pedrioli DM, McLean WH, Moore CB.
Hum Mol Genet. 2016 Mar 15;25(6), 1176-91.


11.
Genomic and exoproteomic analyses of cold- and alkaline-adapted bacteria reveal an abundance of secreted subtilisin-like proteases. Open publication in PubMed
Lylloff JE, Hansen LB, Jepsen M, Sanggaard KW, Vester JK, Enghild JJ, Sørensen SJ, Stougaard P, Glaring MA.
Microb Biotechnol. 2016 Mar;9(2), 245-56.


12.
The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations. Open publication in PubMed
Scavenius C, Nikolajsen CL, Stenvang M, Thøgersen IB, Wyrożemski Ł, Wisniewski HG, Otzen DE, Sanggaard KW, Enghild JJ.
J Biol Chem. 2016 Feb 26;291(9), 4658-70.


13.
Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior. Open publication in PubMed
Amin YY, Runager K, Simoes F, Celiz A, Taresco V, Rossi R, Enghild JJ, Abildtrup LA, Kraft DC, Sutherland DS, Alexander MR, Foss M, Ogaki R.
Adv Mater. 2016 Feb 17;28(7), 1472-6.


14.
Comparative genomic study of arachnid immune systems indicates loss of beta-1,3-glucanase-related proteins and the immune deficiency pathway. Open publication in PubMed
Bechsgaard J, Vanthournout B, Funch P, Vestbo S, Gibbs RA, Richards S, Sanggaard KW, Enghild JJ, Bilde T.
J Evol Biol. 2016 Feb;29(2), 277-91.


15.
LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp). Open publication in PubMed
Poulsen ET, Nielsen NS, Jensen MM, Nielsen E, Hjortdal J, Kim EK, Enghild JJ.
Proteomics. 2016 Feb;16(3), 539-43.


16.
The spider hemolymph clot proteome reveals high concentrations of hemocyanin and von Willebrand factor-like proteins. Open publication in PubMed
Sanggaard KW, Dyrlund TF, Bechsgaard JS, Scavenius C, Wang T, Bilde T, Enghild JJ.
Biochim Biophys Acta. 2016 Feb;1864(2), 233-41.


17.
Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid. Open publication in PubMed
Risør MW, Thomsen LR, Sanggaard KW, Nielsen TA, Thøgersen IB, Lukassen MV, Rossen L, Garcia-Ferrer I, Guevara T, Scavenius C, Meinjohanns E, Gomis-Rüth FX, Enghild JJ.
J Biol Chem. 2016 Jan 29;291(5), 2271-87.


18.
Transglutaminase 2-Catalyzed Intramolecular Cross-Linking of Osteopontin. Open publication in PubMed
Christensen B, Zachariae ED, Scavenius C, Kløverpris S, Oxvig C, Petersen SV, Enghild JJ, Sørensen ES.
Biochemistry. 2016 Jan 19;55(2), 294-303.


2015


1.
New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies. Open publication in PubMed
Poulsen ET, Larsen A, Zollo A, Jørgensen AL, Sanggaard KW, Enghild JJ, Matrone C.
Int J Mol Sci. 2015 Dec 10;16(12), 29446-53.


2.
Hepatocytes respond differently to major dietary trans fatty acid isomers, elaidic acid and trans-vaccenic acid. Open publication in PubMed
Krogager TP, Nielsen LV, Kahveci D, Dyrlund TF, Scavenius C, Sanggaard KW, Enghild JJ.
Proteome Sci. 2015 Dec 1;13, 31.


3.
Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix. Open publication in PubMed
Briggs DC, Birchenough HL, Ali T, Rugg MS, Waltho JP, Ievoli E, Jowitt TA, Enghild JJ, Richter RP, Salustri A, Milner CM, Day AJ.
J Biol Chem. 2015 Nov 27;290(48), 28708-23.


4.
Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase. Open publication in PubMed
Staniec D, Ksiazek M, Thøgersen IB, Enghild JJ, Sroka A, Bryzek D, Bogyo M, Abrahamson M, Potempa J.
J Biol Chem. 2015 Nov 6;290(45), 27248-60.


5.
Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants. Open publication in PubMed
Koldsø H, Andersen OJ, Nikolajsen CL, Scavenius C, Sørensen CS, Underhaug J, Runager K, Nielsen NC, Enghild JJ, Schiøtt B.
Biochemistry. 2015 Sep 15;54(36), 5546-56.


6.
The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile--development of a general synthetic strategy. Open publication in PubMed
Clement LL, Tsakos M, Schaffert ES, Scavenius C, Enghild JJ, Poulsen TB.
Chem Commun (Camb). 2015 Aug 11;51(62), 12427-30.


7.
Protein Composition of TGFBI-R124C- and TGFBI-R555W-Associated Aggregates Suggests Multiple Mechanisms Leading to Lattice and Granular Corneal Dystrophy. Open publication in PubMed
Courtney DG, Poulsen ET, Kennedy S, Moore JE, Atkinson SD, Maurizi E, Nesbit MA, Moore CB, Enghild JJ.
Invest Ophthalmol Vis Sci. 2015 Jul;56(8), 4653-61.


8.
Optimized co-solute paramagnetic relaxation enhancement for the rapid NMR analysis of a highly fibrillogenic peptide. Open publication in PubMed
Oktaviani NA, Risør MW, Lee YH, Megens RP, de Jong DH, Otten R, Scheek RM, Enghild JJ, Nielsen NC, Ikegami T, Mulder FA.
J Biomol NMR. 2015 Jun;62(2), 129-42.


9.
Fibril Core of Transforming Growth Factor Beta-Induced Protein (TGFBIp) Facilitates Aggregation of Corneal TGFBIp. Open publication in PubMed
Sørensen CS, Runager K, Scavenius C, Jensen MM, Nielsen NS, Christiansen G, Petersen SV, Karring H, Sanggaard KW, Enghild JJ.
Biochemistry. 2015 Maj 19;54(19), 2943-56.


10.
KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure. Open publication in PubMed
Ksiazek M, Mizgalska D, Eick S, Thøgersen IB, Enghild JJ, Potempa J.
Front Microbiol. 2015 Apr 21;6, 312.


11.
The effects of hypochlorous acid and neutrophil proteases on the structure and function of extracellular superoxide dismutase. Open publication in PubMed
Morales K, Olesen MN, Poulsen ET, Larsen UG, Enghild JJ, Petersen SV.
Free Radic Biol Med. 2015 Apr;81, 38-46.


12.
Characterization of the gila monster (Heloderma suspectum suspectum) venom proteome. Open publication in PubMed
Sanggaard KW, Dyrlund TF, Thomsen LR, Nielsen TA, Brøndum L, Wang T, Thøgersen IB, Enghild JJ.
J Proteomics. 2015 Mar 18;117, 1-11.


13.
Mirolase, a novel subtilisin-like serine protease from the periodontopathogen Tannerella forsythia. Open publication in PubMed
Ksiazek M, Karim AY, Bryzek D, Enghild JJ, Thøgersen IB, Koziel J, Potempa J.
Biol Chem. 2015 Mar;396(3), 261-75.


14.
ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). Open publication in PubMed
Shitomi Y, Thøgersen IB, Ito N, Leitinger B, Enghild JJ, Itoh Y.
Mol Biol Cell. 2015 Feb 15;26(4), 659-73.


15.
Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. Open publication in PubMed
Ksiazek M, Mizgalska D, Enghild JJ, Scavenius C, Thogersen IB, Potempa J.
J Biol Chem. 2015 Jan 2;290(1), 658-70.


2014


1.
Identification of transglutaminase reactive residues in human osteopontin and their role in polymerization. Open publication in PubMed
Christensen B, Zachariae ED, Scavenius C, Thybo M, Callesen MM, Kløverpris S, Oxvig C, Enghild JJ, Sørensen ES.
PLoS One. 2014 Nov 24;9(11), e113650.


2.
Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity. Open publication in PubMed
Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa J.
J Biol Chem. 2014 Nov 21;289(47), 32481-7.


3.
Carbamylation of immunoglobulin abrogates activation of the classical complement pathway. Open publication in PubMed
Koro C, Bielecka E, Dahl-Knudsen A, Enghild JJ, Scavenius C, Brun JG, Binder V, Hellvard A, Bergum B, Jonsson R, Potempa J, Blom AM, Mydel P.
Eur J Immunol. 2014 Nov;44, 3403-12.


4.
Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity. Open publication in PubMed
Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa J.
J Biol Chem. 2014 Nov;13, 4659-67.


5.
Unconditioned commercial embryo culture media contain a large variety of non-declared proteins: a comprehensive proteomics analysis. Open publication in PubMed
Dyrlund TF, Kirkegaard K, Poulsen ET, Sanggaard KW, Hindkjær JJ, Kjems J, Enghild JJ, Ingerslev HJ.
Hum Reprod. 2014 Nov;29(11), 2421-30.


6.
Incorporation of pentraxin 3 into hyaluronan matrices is tightly regulated and promotes matrix cross-linking. Open publication in PubMed
Baranova NS, Inforzato A, Briggs DC, Tilakaratna V, Enghild JJ, Thakar D, Milner CM, Day AJ, Richter RP.
J Biol Chem. 2014 Okt 31;289(44), 30481-98.


7.
Proteome analysis of human sebaceous follicle infundibula extracted from healthy and acne-affected skin. Open publication in PubMed
Bek-Thomsen M, Lomholt HB, Scavenius C, Enghild JJ, Brüggemann H.
PLoS One. 2014 Sep 19;9(9), e107908.


8.
Template-directed covalent conjugation of DNA to native antibodies, transferrin and other metal-binding proteins. Open publication in PubMed
Rosen CB, Kodal AL, Nielsen JS, Schaffert DH, Scavenius C, Okholm AH, Voigt NV, Enghild JJ, Kjems J, Tørring T, Gothelf KV.
Nat Chem. 2014 Sep;6, 804-9.


9.
Unconditioned commercial embryo culture media contain a large variety of non-declared proteins: a comprehensive proteomics analysis. Open publication in PubMed
Dyrlund TF, Kirkegaard K, Poulsen ET, Sanggaard KW, Hindkjær JJ, Kjems J, Enghild JJ, Ingerslev HJ.
Hum Reprod. 2014 Aug 27;[Epub ahead of print].


10.
Proteomics of Fuchs Endothelial Corneal Dystrophy support that the extracellular matrix of Descemets membrane is disordere Open publication in PubMed
Poulsen ET, Dyrlund TF, Runager K, Scavenius C, Krogager TP, Hojrup P, Thøgersen IB, Sanggaard KW, Vorum H, Hjortdal J, Enghild JJ.
J Proteome Res. 2014 Maj 21;[Epub ahead of print].


11.
The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain Open publication in PubMed
Risør MW, Poulsen ET, Thomsen LR, Dyrlund TF, Nielsen TA, Nielsen NC, Sanggaard KW, Enghild JJ.
Biochemistry. 2014 Maj 20;[Epub ahead of print].


12.
Spider genomes provide insight into composition and evolution of venom and silk. Open publication in PubMed
Sanggaard KW, Bechsgaard JS, Fang X, Duan J, Dyrlund TF, Gupta V, Jiang X, Cheng L, Fan D, Feng Y, Han L, Huang Z, Wu Z, Liao L, Settepani V, Thøgersen IB, Vanthournout B, Wang T, Zhu Y, Funch P, Enghild JJ, Schauser L, Andersen SU, Villesen P, Schierup MH, Bilde T, Wang J.
Nat Commun. 2014 Maj 6;5:3765.


13.
Preparation of uniformly 13C,15N-labeled recombinant human amylin for solid-state NMR investigation. Open publication in PubMed
Kosicka I, Kristensen T, Bjerring M, Thomsen K, Scavenius C, Enghild JJ, Nielsen NC.
Protein Expr Purif. 2014 Apr 19;[Epub ahead of print].


14.
KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure. Open publication in PubMed
Ksiazek M, Mizgalska D, Eick S, Thøgersen IB, Enghild JJ, Potempa J.
Front Microbiol. 2014 Apr;21.


15.
Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. Open publication in PubMed
Milutinovic PS, Englert JM, Crum LT, Mason NS, Ramsgaard L, Enghild JJ, Sparvero LJ, Lotze MT, Oury TD.
PLoS One. 2014 Mar 18;9(3).


16.
The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation. Open publication in PubMed
Lorenzen N, Nielsen SB, Buell AK, Kaspersen JD, Arosio P, Vad BS, Paslawski W, Christiansen G, Valnickova-Hansen Z, Andreasen M, Enghild JJ, Pedersen JS, Dobson CM, Knowles TP, Otzen DE.
J Am Chem Soc. 2014 Mar 14;136(10):3859-68.


17.
Coagulation Factor XIIIa Substrates in Human Plasma. Identification and Incorporation Into the Clot Open publication in PubMed
Nikolajsen CL, Dyrlund TF, Toftgaard Poulsen E, Enghild JJ, Scavenius C.
J Biol Chem. 2014 Mar 7;289.


2013


1.
Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene Open publication in PubMed
Poulsen ET, Runager K, Risør MW, Dyrlund TF, Scavenius C, Karring H, Praetorius J, Vorum H, Otzen DE, Klintworth GK, Enghild JJ.
Proteomics Clin Appl. 2013 Dec 2;[Epub ahead of print].


2.
Proteome reference maps of the Lotus japonicus nodule and root. Open publication in PubMed
Dam S, Dyrlund TF, Ussatjuk A, Jochimsen B, Nielsen K, Goffard N, Ventosa M, Lorentzen A, Gupta V, Andersen SU, Enghild JJ, Ronson CW, Roepstorff P, Stougaard J.
Proteomics. 2013 Nov 29;[Epub ahead of print].


3.
Secreted major Venus flytrap chitinase enables digestion of Arthropod prey. Open publication in PubMed
Paszota P, Escalante-Perez M, Thomsen LR, Risør MW, Dembski A, Sanglas L, Nielsen TA, Karring H, Thøgersen IB, Hedrich R, Enghild JJ, Kreuzer I, Sanggaard KW.
Biochim Biophys Acta. 2013 Nov 22;[Epub ahead of print].


4.
Species Differences Take Shape at Nanoparticles: Protein Corona Made of the Native Repertoire Assists Cellular Interaction. Open publication in PubMed
Hayashi Y, Miclaus T, Scavenius C, Kwiatkowska K, Sobota A, Engelmann P, Scott-Fordsmand JJ, Enghild JJ, Sutherland DS.
Environ Sci Technol. 2013 Nov 22;[Epub ahead of print].


5.
Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization. Open publication in PubMed
Underhaug J, Koldsø H, Runager K, Nielsen JT, Sørensen CS, Kristensen T, Otzen DE, Karring H, Malmendal A, Schiøtt B, Enghild JJ, Nielsen NC.
Biochim Biophys Acta. 2013 Okt 12;S1570-9639(13)00366-X.


6.
Effects of Elaidic Acid on Lipid Metabolism in HepG2 Cells, Investigated by an Integrated Approach of Lipidomics, Transcriptomics and Proteomics Open publication in PubMed
Vendel Nielsen L, Krogager TP, Young C, Ferreri C, Chatgilialoglu C, Nørregaard Jensen O, Enghild JJ.
PLoS One. 2013 Sep 13;8(9).


7.
Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules. Open publication in PubMed
Cheema MU, Poulsen ET, Enghild JJ, Hoorn E, Fenton RA, Praetorius J.
Physiol Rep. 2013 Sep 10;[Epub ahead of print].


8.
Inter-á-Inhibitor Impairs TSG-6-Induced Hyaluronan Cross-Linking Open publication in PubMed
Baranova NS, Foulcer SJ, Briggs DC, Tilakaratna V, Enghild JJ, Milner CM, Day AJ, Richter RP.
J Biol Chem. 2013. 2013 Sep 4;[Epub ahead of print].


9.
The Human Eye Proteome Project: Perspectives on an emerging proteome Open publication in PubMed
Semba RD, Enghild JJ, Venkatraman V, Dyrlund TF, Van Eyk JE.
Proteomics. 2013 Aug 13;13(16):2500-11.


10.
Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases Open publication in PubMed
Veillard F, Sztukowska M, Mizgalska D, Ksiazek M, Houston J, Potempa B, Enghild JJ, Thogersen IB, Gomis-Rüth FX, Nguyen KA, Potempa J.
Biochim Biophys Acta. 2013 Aug;1830(8):4218-28.


11.
Investigations on collectin liver 1 Open publication in PubMed
Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC.
J Biol Chem. 2013 Aug;9.


12.
Murine Extracellular Superoxide Dismutase Is Converted into the Inactive Fold by the Ser195Cys Mutation Open publication in PubMed
Scavenius C, Petersen JS, Thomsen LR, Poulsen ET, Valnickova-Hansen Z, Bowler RP, Oury TD, Petersen SV, Enghild JJ.
Biochemistry. 2013 Maj 1;[Epub ahead of print].


13.
The insoluble TGFBIp-fraction of the cornea is covalently linked via a disulfide bond to type XII collagen. Open publication in PubMed
Runager K, Klintworth GK, Karring H, Enghild JJ.
Biochemistry. 2013 Apr 23;52(16):2821-7.


14.
Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits Open publication in PubMed
Karring H, Poulsen ET, Runager K, Thøgersen IB, Klintworth GK, Højrup P, Enghild JJ.
Mol Vis. 2013 Apr 12;19:861-76.


15.
Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: interactions with human β2 integrins and erythrocytes. Open publication in PubMed
Reinholdt J, Poulsen K, Brinkmann CR, Hoffmann SV, Stapulionis R, Enghild JJ, Jensen UB, Boesen T, Vorup-Jensen .
Biochim Biophys Acta. 2013 Feb;1834(2):546-58.


16.
Off-pathway aggregation can inhibit fibrillation at high protein concentrations Open publication in PubMed
Deva T, Lorenzen N, Vad BS, Petersen SV, Thørgersen I, Enghild JJ, Kristensen T, Otzen DE.
Biochim Biophys Acta. 2013 Feb;1834(3):677-87.


17.
Physicochemical characterization of fish protein adlayers with bacteria repelling properties. Open publication in PubMed
Meyer RL, Arpanaei A, Pillai S, Bernbom N, Enghild JJ, Ng YY, Gram L, Besenbacher F, Kingshott P.
Colloids Surf B Biointerfaces. 2013 Feb;1;102:504-10.


18.
Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition Open publication in PubMed
Gottfredsen RH, Larsen UG, Enghild JJ, Petersen SV.
Redox Biol. 2013 Jan 11;1(1):24-31.


19.
Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1. Open publication in PubMed
Scilabra SD, Troeberg L, Yamamoto K, Emonard H, Thøgersen I, Enghild JJ, Strickland DK, Nagase H.
J Biol Chem. 2013 Jan;4;288(1):332-42.


20.
Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage. Open publication in PubMed
Pyrc K, Milewska A, Kantyka T, Sroka A, Maresz K, Kozieł J, Nguyen KA, Enghild JJ, Knudsen AD, Potempa J.
Infect Immun. 2013 Jan;81(1):55-64.


2012


1.
Unique structural features facilitate lizard tail autotomy Open publication in PubMed
Sanggaard KW, Danielsen CC, Wogensen L, Vinding MS, Rydtoft LM, Mortensen MB, Karring H, Nielsen NC, Wang T, Thøgersen IB, Enghild JJ.
PLoS One. 2012 Dec 19;7(12):e51803.


2.
Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: interactions with human â2 integrins and erythrocytes Open publication in PubMed
Reinholdt J, Poulsen K, Brinkmann CR, Hoffmann SV, Stapulionis R, Enghild JJ, Jensen UB, Boesen T, Vorup-Jensen T.
Biochim Biophys Acta. 2012 Dec 9;2013 Feb;1834(2):546-58.


3.
Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound And Shed Low Density Lipoprotein Receptor-related Protein 1. Open publication in PubMed
Scilabra SD, Troeberg L, Yamamoto K, Emonard H, Thogersen I, Enghild JJ, Strickland DK, Nagase H.
J Biol Chem. 2012. 2012 Nov 19;[Epub ahead of print].


4.
The protein composition of the digestive fluid from the Venus flytrap sheds light on prey digestion mechanisms. Open publication in PubMed
Sanggaard KW, Schulze WX, Kreuzer I, Knudsen AD, Bemm F, Thogersen IB, Brautigam A, Thomsen LR, Schliesky S, Dyrlund TF, Escalante-Perez M, Becker D, Schultz J, Karring H, Weber A, Hojrup P, Hedrich R, Enghild JJ.
Mol Cell Proteomics. 2012 Nov 11;11(11):1306-19.


5.
Vesicular signalling and immune modulation as hedonic fingerprints: proteomic profiling in the chronic mild stress depression model. Open publication in PubMed
Bisgaard CF, Bak S, Christensen T, Jensen ON, Enghild JJ, Wiborg O.
J Psychopharmacol. 2012 Nov 8;[Epub ahead of print].


6.
Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage Open publication in PubMed
Pyrc K, Milewska A, Kantyka T, Sroka A, Maresz K, Koziel J, Nguyen KA, Enghild JJ, Knudsen AD, Potempa J.
Infect Immun. 2012 Okt 22;[Epub ahead of print].


7.
Polymorphic fibrillation of the destabilized 4th fasciclin-1 domain mutant A546T of the transforming growth factor-â induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates. Open publication in PubMed
Andreasen M, Nielsen SB, Runager K, Christiansen G, Nielsen NC, Enghild JJ, Otzen DE.
J Biol Chem. 2012 Okt 5;287(41):34730-42.


8.
Synthesis and Evaluation of Silanediols as Highly Selective Uncompetitive Inhibitors of Human Neutrophil Elastase. Open publication in PubMed
Madsen JL, Andersen TL, Santamaria S, Nagase H, Enghild JJ, Skrydstrup T.
J Med Chem. 2012 Sep 13;55(17):7900-8.


9.
MS Data Miner: A web-based software tool to analyze, compare and share mass spectrometry protein identifications. Open publication in PubMed
Dyrlund TF, Poulsen ET, Scavenius C, Sanggaard KW, Enghild JJ.
Proteomics. 2012 Sep 12;18:2792-6.


10.
The neuroendocrine protein 7B2 is intrinsically disordered. Open publication in PubMed
Dasgupta I, Sanglas L, Enghild JJ, Lindberg I.
Biochemistry. 2012 Sep 4;[Epub ahead of print].


11.
Physicochemical characterization of fish protein adlayers with bacteria repelling properties. Open publication in PubMed
Meyer RL, Arpanaei A, Pillai S, Bernbom N, Enghild JJ, Ng YY, Gram L, Besenbacher F, Kingshott P.
Colloids Surf B Biointerfaces. 2012 Sep 2;[Epub ahead of print].


12.
Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes. Open publication in PubMed
Sztukowska M, Veillard F, Potempa B, Bogyo M, Enghild JJ, Thogersen IB, Nguyen KA, Potempa J.
Biol Chem. . 2012 Sep 1;393(9):971-7.


13.
Human cornea proteome: Identification and quantitation of the proteins of the three main layers including epithelium, stroma and endothelium Open publication in PubMed
Dyrlund TF, Poulsen ET, Scavenius C, Nikolajsen CL, Thøgersen IB, Vorum H, Enghild JJ.
J Proteome Res. 2012 Aug 3;11(8):4231-9. .


14.
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1 Open publication in PubMed
Manka SW, Carafoli F, Visse R, Bihan D, Raynal N, Farndale RW, Murphy G, Enghild JJ, Hohenester E, Nagase H.
Proc Natl Acad Sci U S A. 2012 Jul 3;.


15.
Human Complement C3 is a Substrate for Transglutaminases. A functional link between non-protease based members of the coagulation and complement cascades. Open publication in PubMed
Nikolajsen CL, Scavenius C, Enghild JJ.
Biochemistry. 2012 Jun 12;51(23):4735-42.


16.
Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1). Open publication in PubMed
Krogager TP, Nielsen LV, Bak S, Young C, Ferreri C, Jensen ON, Højrup P, Thoma V, Thøgersen IB, Enghild JJ.
J Proteomics. 2012 Maj 17;75(9):2685-96.


17.
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. Open publication in PubMed
Karring H, Runager K, Thøgersen IB, Klintworth GK, Højrup P, Enghild JJ.
Exp Eye Res. 2012 Mar;96(1):163-70.


18.
The C-terminal proteolytic processing of extracellular superoxide dismutase is redox regulated. Open publication in PubMed
Gottfredsen RH, Tran SM, Larsen UG, Madsen P, Nielsen MS, Enghild JJ, Petersen SV.
Free Radic Biol Med. 2012 Jan 1;52(1):191-7.


2011


1.
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. Open publication in PubMed
Karring H, Runager K, Thøgersen IB, Klintworth GK, Højrup P, Enghild JJ.
Exp Eye Res. 2011 Dec 3;.


2.
Human inter-á-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. Open publication in PubMed
Scavenius C, Sanggaard KW, Nikolajsen CL, Bak S, Valnickova Z, Thøgersen IB, Jensen ON, Højrup P, Enghild JJ.
Biochim Biophys Acta. 2011 Dec;1814(12).


3.
The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: The monoclonal antibody KIM185 to CD18 also binds C4-binding protein. Open publication in PubMed
Gjelstrup LC, Andersen SH, Petersen SV, Enghild JJ, Blom AM, Vorup-Jensen T, Thiel S.
Mol Immunol. 2011 Aug 17;.


4.
Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis. Open publication in PubMed
Skottrup PD, Leonard P, Kaczmarek JZ, Veillard F, Enghild JJ, OKennedy R, Sroka A, Clausen RP, Potempa J, Riise E.
Anal Biochem. 2011 Aug 15;415(2):158-67.


5.
Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice. Open publication in PubMed
Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD.
PLoS One. 2011 Maj 23;6(5).


6.
SAXS Models of TGFBIp Reveal a Trimeric Structure and Show That the Overall Shape Is Not Affected by the Arg124His Mutation. Open publication in PubMed
Basaiawmoit RV, Oliveira CL, Runager K, Sørensen CS, Behrens MA, Jonsson BH, Kristensen T, Klintworth GK, Enghild JJ, Pedersen JS, Otzen DE.
J Mol Biol. 2011 Maj 6;408(3):503-13.


7.
Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence. Open publication in PubMed
Kantyka T, Plaza K, Koziel J, Florczyk D, Stennicke HR, Thogersen IB, Enghild JJ, Silverman GA, Pak SC, Potempa J.
Biol Chem. 2011 Maj;392(5):483-9.


8.
Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp Open publication in PubMed
Runager K, Basaiawmoit RV, Deva T, Andreasen M, Valnickova Z, Sørensen CS, Karring H, Thøgersen IB, Christiansen G, Underhaug J, Kristensen T, Nielsen NC, Klintworth GK, Otzen DE, Enghild JJ.
J Biol Chem. 2011 Feb 18;286(7).


2010


1.
NMR Reveals Two-Step Association of Congo Red to Amyloid â in Low-Molecular-Weight Aggregates. Open publication in PubMed
Pedersen MO, Mikkelsen K, Behrens MA, Pedersen JS, Enghild JJ, Skrydstrup T, Malmendal A, Nielsen NC.
J Phys Chem B. 2010 Dec 9;114(48):16003-10.


2.
Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates. Open publication in PubMed
Valnickova Z, Sanglas L, Arolas JL, Petersen SV, Schar C, Otzen D, Aviles FX, Gomis-Ruth FX, Enghild JJ.
J Biol Chem. 2010 Dec 3;285(49):38243-50.


3.
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications. Open publication in PubMed
Lim NH, Kashiwagi M, Visse R, Jones J, Enghild JJ, Brew K, Nagase H.
Biochem J. 2010 Okt 1;431(1):113-22.


4.
The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis. Open publication in PubMed
Petersen SV, Thøgersen IB, Valnickova Z, Nielsen MS, Petersen JS, Poulsen ET, Jacobsen C, Oury TD, Moestrup SK, Crapo JD, Nielsen NC, Kristensen T, Enghild JJ.
Free Radic Biol Med. 2010 Sep 1;49(5):894-9.


5.
The TSG-6/HC2-mediated transfer is a dynamic process shuffling HCs between glycosaminoglycans Open publication in PubMed
Sanggaard KW, Scavenius C, Rasmussen AJ, Wisniewski HG, Thogersen IB, Enghild JJ.
J Biol Chem. 2010 Jul 16;285(29):21988-93.


6.
Functional amyloid in Pseudomonas Open publication in PubMed
Dueholm MS, Petersen SV, Sønderkær M, Larsen P, Christiansen G, Hein KL, Enghild JJ, Nielsen JL, Nielsen KL, Nielsen PH, Otzen DE.
Mol Microbiol. 2010 Jun 21;[Epub ahead of print].


7.
Glucagon Fibril Polymorphism Reflects Differences in Protofilament Backbone Structure. Open publication in PubMed
Andersen CB, Hicks MR, Vetri V, Vandahl B, Rahbek-Nielsen H, Thøgersen H, Thøgersen IB, Enghild JJ, Serpell LC, Rischel C, Otzen DE.
J Mol Biol. 2010 Apr 9;397(4):932-46.


8.
Divorcing folding from function: How acylation affects the membrane-perturbing properties of an antimicrobial peptide. Open publication in PubMed
Vad B, Thomsen LA, Bertelsen K, Franzmann M, Pedersen JM, Nielsen SB, Vosegaard T, Valnickova Z, Skrydstrup T, Enghild JJ, Wimmer R, Nielsen NC, Otzen DE.
Biochim Biophys Acta. 2010 Apr;1804(4):806-820.


9.
Evolutionary conservation of heavy chain protein transfer between glycosaminoglycans. Open publication in PubMed
Sanggaard KW, Hansen L, Scavenius C, Wisniewski HG, Kristensen T, Thøgersen IB, Enghild JJ.
Biochim Biophys Acta. 2010 Apr;1804(4):1011-1019.


10.
The role of the receptor for advanced glycation end-products in a murine model of silicosis Open publication in PubMed
Ramsgaard L, Englert JM, Tobolewski J, Tomai L, Fattman CL, Leme AS, Kaynar AM, Shapiro SD, Enghild JJ, Oury TD.
PLoS One. 2010 Mar;5(3):e9604.


11.
The diversity of FtsY-lipid interactions. Open publication in PubMed
Reinau ME, Thøgersen IB, Enghild JJ, Nielsen KL, Otzen DE.
Biopolymers. 2010 Feb 9;[Epub ahead of print].


12.
Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa. Open publication in PubMed
Sanglas L, Arolas JL, Valnickova Z, Aviles FX, Enghild JJ, Gomis-Rüth FX.
J Thromb Haemost. 2010 Jan 17;[Epub ahead of print].


13.
A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037. Open publication in PubMed
Karim AY, Kulczycka M, Kantyka T, Dubin G, Jabaiah A, Daugherty PS, Thogersen IB, Enghild JJ, Nguyen KA, Potempa J.
Biol Chem. 2010 Jan;391(1):105-17.


14.
Differential expression and processing of transforming growth factor beta induced protein (TGFBIp) in the normal human cornea during postnatal development and aging. Open publication in PubMed
Karring H, Runager K, Valnickova Z, Thøgersen IB, Møller-Pedersen T, Klintworth GK, Enghild JJ.
Exp Eye Res. 2010 Jan;90(1):57-62.


2009


1.
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Open publication in PubMed
Troeberg L, Fushimi K, Scilabra SD, Nakamura H, Dive V, Thøgersen IB, Enghild JJ, Nagase H.
Matrix Biol. 2009 Okt;28(8):463-9.


2.
Potential clinical importance of the activation peptide of prostate-specific antigen. Open publication in PubMed
Voeghtly LM, Thøgersen IB, Valnickova Z, Sanggaard KW, Chu CT, Oury TD, Enghild JJ.
Int J Clin Exp Pathol. 2009 Jun 20;2(6):588-98.


3.
Widespread abundance of functional bacterial amyloid in mycolata and other gram-positive bacteria. Open publication in PubMed
Jordal PB, Dueholm MS, Larsen P, Petersen SV, Enghild JJ, Christiansen G, Højrup P, Nielsen PH, Otzen DE.
Appl Environ Microbiol. 2009 Jun;75(12):4101-10.


4.
Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI). Open publication in PubMed
Valnickova Z, Thaysen-Andersen M, Højrup P, Christensen T, Sanggaard KW, Kristensen T, Enghild JJ.
BMC Biochem. 2009 Maj 5;10:13.


5.
Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus. Open publication in PubMed
Stec-Niemczyk J, Pustelny K, Kisielewska M, Bista M, Boulware KT, Stennicke HR, Thogersen IB, Daugherty PS, Enghild JJ, Baczynski K, Popowicz GM, Dubin A, Potempa J, Dubin G.
Biochem J. 2009 Maj 1;419(3):555-64.


6.
Purification, crystallization and preliminary X-ray diffraction of wild-type and mutant recombinant human transforming growth factor beta-induced protein (TGFBIp). Open publication in PubMed
Runager K, García-Castellanos R, Valnickova Z, Kristensen T, Nielsen NC, Klintworth GK, Gomis-Rüth FX, Enghild JJ.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):299-303.


7.
Stable intermediates determine proteins' primary unfolding sites in the presence of surfactants. Open publication in PubMed
Hansen JH, Petersen SV, Andersen KK, Enghild JJ, Damhus T, Otzen D.
Biopolymers. 2009 Mar;91(3):221-31.


8.
The proteome of seed development in the model legume Lotus japonicus. Open publication in PubMed
Dam S, Laursen BS, Ornfelt JH, Jochimsen B, Staerfeldt HH, Friis C, Nielsen K, Goffard N, Besenbacher S, Krusell L, Sato S, Tabata S, Thøgersen IB, Enghild JJ, Stougaard J.
Plant Physiol. 2009 Mar;149(3):1325-40.


9.
Transfer of inter-alpha-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes. Open publication in PubMed
Colón E, Shytuhina A, Cowman MK, Band PA, Sanggaard KW, Enghild JJ, Wisniewski HG.
J Biol Chem. 2009 Jan 23;284(4):2320-31.


10.
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. Open publication in PubMed
Halaban R, Krauthammer M, Pelizzola M, Cheng E, Kovacs D, Sznol M, Ariyan S, Narayan D, Bacchiocchi A, Molinaro A, Kluger Y, Deng M, Tran N, Zhang W, Picardo M, Enghild JJ.
PLoS One. 2009;4(2):e4563.


2008


1.
TSG-6 transfers proteins between glycosaminoglycans via a Ser28-mediated covalent catalytic mechanism. Open publication in PubMed
Sanggaard KW, Sonne-Schmidt CS, Krogager TP, Kristensen T, Wisniewski HG, Thøgersen IB, Enghild JJ.
J Biol Chem. 2008 Dec 5;283(49):33919-26.


2.
The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa. Open publication in PubMed
Anand K, Pallares I, Valnickova Z, Christensen T, Vendrell J, Wendt KU, Schreuder HA, Enghild JJ, Avilés FX.
J Biol Chem. 2008 Okt 24;283(43):29416-23.


3.
Focus on molecules: Transforming growth factor beta induced protein (TGFBIp). Open publication in PubMed
Runager K, Enghild JJ, Klintworth GK.
Exp Eye Res. 2008 Okt;87(4):298-9.


4.
Large scale isolation and purification of soluble RAGE from lung tissue. Open publication in PubMed
Englert JM, Ramsgaard L, Valnickova Z, Enghild JJ, Oury TD.
Protein Expr Purif. 2008 Sep;61(1):99-101.


5.
Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis. Open publication in PubMed
Sanglas L, Valnickova Z, Arolas JL, Pallarés I, Guevara T, Solà M, Kristensen T, Enghild JJ, Aviles FX, Gomis-Rüth FX.
Mol Cell. 2008 Aug 22;31(4):598-606.


6.
The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. Open publication in PubMed
Sanggaard KW, Sonne-Schmidt CS, Krogager TP, Lorentzen KA, Wisniewski HG, Thøgersen IB, Enghild JJ.
J Biol Chem. 2008 Jul 4;283(27):18530-7.


7.
Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln. Open publication in PubMed
Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz GM, Bista M, Kantyka T, Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Daugherty PS, Thøgersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J.
J Mol Biol. 2008 Maj 30;379(2):343-56.


8.
The folding of human active and inactive extracellular superoxide dismutases is an intracellular event. Open publication in PubMed
Petersen SV, Kristensen T, Petersen JS, Ramsgaard L, Oury TD, Crapo JD, Nielsen NC, Enghild JJ.
J Biol Chem. 2008 Maj 30;283(22):15031-6.


9.
Atypical asymmetric lattice corneal dystrophy associated with a novel homozygous mutation (Val624Met) in the TGFBI gene. Open publication in PubMed
Afshari NA, Bahadur RP, Eifrig DE Jr, Thogersen IB, Enghild JJ, Klintworth GK.
Mol Vis. 2008 Mar 12;14:495-9.


10.
Investigating the biomarker potential of glycoproteins using comparative glycoprofiling - application to tissue inhibitor of metalloproteinases-1. Open publication in PubMed
Thaysen-Andersen M, Thøgersen IB, Lademann U, Offenberg H, Giessing AM, Enghild JJ, Nielsen HJ, Brünner N, Højrup P.
Biochim Biophys Acta. 2008 Mar;1784(3):455-63.


11.
A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. Open publication in PubMed
Mallorquí-Fernández N, Manandhar SP, Mallorquí-Fernández G, Usón I, Wawrzonek K, Kantyka T, Solà M, Thøgersen IB, Enghild JJ, Potempa J, Gomis-Rüth FX.
J Biol Chem. 2008 Feb 1;283(5):2871-82.


12.
Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Open publication in PubMed
Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD.
Antioxid Redox Signal. 2008 Feb;10(2):261-8.


13.
Human skin keratins are the major proteins in exhaled breath condensate. Open publication in PubMed
Hoffmann HJ, Tabaksblat LM, Enghild JJ, Dahl R.
Eur Respir J. 2008 Feb;31(2):380-4.


14.
Catalytic properties of ADAM12 and its domain deletion mutants. Open publication in PubMed
Jacobsen J, Visse R, Sørensen HP, Enghild JJ, Brew K, Wewer UM, Nagase H.
Biochemistry. 2008 Jan 15;47(2):537-47.


2007


1.
Optimal control based NCO and NCA experiments for spectral assignment in biological solid-state NMR spectroscopy. Open publication in PubMed
Kehlet C, Bjerring M, Sivertsen AC, Kristensen T, Enghild JJ, Glaser SJ, Khaneja N, Nielsen NC.
J Magn Reson. 2007 Jan;188(2):216-30.


2.
The subunit composition of human extracellular superoxide dismutase (EC-SOD) regulates enzymatic activity. Open publication in PubMed
Petersen SV, Valnickova Z, Oury TD, Crapo JD, Chr Nielsen N, Enghild JJ.
BMC Biochem. 2007 Okt 15;8:19.


3.
Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene. Open publication in PubMed
Karring H, Valnickova Z, Thøgersen IB, Hedegaard CJ, Møller-Pedersen T, Kristensen T, Klintworth GK, Enghild JJ.
Mol Vis. 2007 Jul 27;13:997-1004.


4.
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. Open publication in PubMed
Gendron C, Kashiwagi M, Lim NH, Enghild JJ, Thøgersen IB, Hughes C, Caterson B, Nagase H.
J Biol Chem. 2007 Jun 22;282(25):18294-306.


5.
The intrinsic enzymatic activity of procarboxypeptidase U (TAFI) does not significantly influence the fibrinolytic rate: reply to a rebuttal. Open publication in PubMed
Valnickova Z, Thøgersen IB, Potempa J, Enghild JJ.
J Thromb Haemost. 2007 Jun;5(6):1336-7.


6.
Rapid and individual-specific glycoprofiling of the low abundance N-glycosylated protein tissue inhibitor of metalloproteinases-1. Open publication in PubMed
Thaysen-Andersen M, Thøgersen IB, Nielsen HJ, Lademann U, Brünner N, Enghild JJ, Højrup P.
Mol Cell Proteomics. 2007 Apr;6(4):638-47.


7.
The major allergen from birch tree pollen, Bet v 1, binds and permeabilizes membranes. Open publication in PubMed
Mogensen JE, Ferreras M, Wimmer R, Petersen SV, Enghild JJ, Otzen DE.
Biochemistry. 2007 Mar 20;46(11):3356-65.


8.
Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung. Open publication in PubMed
Lizotte PP, Hanford LE, Enghild JJ, Nozik-Grayck E, Giles BL, Oury TD.
BMC Dev Biol. 2007 Mar 7;7:15.


9.
Heparin binding induces a conformational change in pigment epithelium-derived factor. Open publication in PubMed
Valnickova Z, Petersen SV, Nielsen SB, Otzen DE, Enghild JJ.
J Biol Chem. 2007 Mar 2;282(9):6661-7.


10.
Thrombin-activable fibrinolysis inhibitor (TAFI) zymogen is an active carboxypeptidase. Open publication in PubMed
Valnickova Z, Thøgersen IB, Potempa J, Enghild JJ.
J Biol Chem. 2007 Feb 2;282(5):3066-76.


11.
A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex Open publication in PubMed
Nielsen MJ, Petersen SV, Jacobsen C, Thirup S, Enghild JJ, Graversen JH, Moestrup SK.
J Biol Chem. 2007 Jan 12;282(2):1072-9.


12.
Proteomic investigation of the ventral rat hippocampus links DRP-2 to escitalopram treatment resistance and SNAP to stress resilience in the chronic mild stress model of depression. Open publication in PubMed
Bisgaard CF, Jayatissa MN, Enghild JJ, Sanchéz C, Artemychyn R, Wiborg O.
J Mol Neurosci. 2007. 2007;32(2):132-44.


2006


1.
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes. Open publication in PubMed
Sanggaard KW, Sonne-Schmidt CS, Jacobsen C, Thøgersen IB, Valnickova Z, Wisniewski HG, Enghild JJ.
Biochemistry. 2006 Jun 20;45(24):7661-8.


2.
The human cornea proteome: bioinformatic analyses indicate import of plasma proteins into the cornea. Open publication in PubMed
Karring H, Thøgersen IB, Klintworth GK, Møller-Pedersen T, Enghild JJ.
Mol Vis. 2006 Maj 9;12:451-60.


3.
Extracellular superoxide dismutase exists as an octamer Open publication in PubMed
Due AV, Petersen SV, Valnickova Z, Østergaard L, Oury TD, Crapo JD, Enghild JJ.
FEBS Lett. 2006 Feb 20;580(5):1485-9.


4.
Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation. Open publication in PubMed
Valnickova Z, Christensen T, Skottrup P, Thøgersen IB, Højrup P, Enghild JJ.
Biochemistry. 2006 Feb 7;45(5):1525-35.


2005


1.
A dataset of human cornea proteins identified by Peptide mass fingerprinting and tandem mass spectrometry. Open publication in PubMed
Karring H, Thøgersen IB, Klintworth GK, Møller-Pedersen T, Enghild JJ.
Mol Cell Proteomics. 2005 Sep;4(9):1406-8.


2.
Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. Open publication in PubMed
Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS.
J Biol Chem. 2005 Jun 24;280(25):23778-84.


3.
Extracellular superoxide dismutase: structural and functional considerations of a protein shaped by two different disulfide bridge patterns. Open publication in PubMed
Petersen SV, Enghild JJ.
Biomed Pharmacother. 2005 Maj;59(4):175-82.


4.
The TSG-6 and I alpha I interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link. Open publication in PubMed
Sanggaard KW, Karring H, Valnickova Z, Thøgersen IB, Enghild JJ.
J Biol Chem. 2005 Mar 25;280(12):11936-42.


5.
The high concentration of Arg213-->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. Open publication in PubMed
Petersen SV, Olsen DA, Kenney JM, Oury TD, Valnickova Z, Thøgersen IB, Crapo JD, Enghild JJ.
Biochem J. 2005 Jan 15;385(Pt 2):427-32.


2004


1.
Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE). Open publication in PubMed
Hanford LE, Enghild JJ, Valnickova Z, Petersen SV, Schaefer LM, Schaefer TM, Reinhart TA, Oury TD.
J Biol Chem. 2004 Nov 26;279(48):50019-24.


2.
Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Open publication in PubMed
Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW.
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1095-104.


3.
Proteomic analysis of the soluble fraction from human corneal fibroblasts with reference to ocular transparency. Open publication in PubMed
Karring H, Thøgersen IB, Klintworth GK, Enghild JJ, Møller-Pedersen T.
Mol Cell Proteomics. 2004 Jun;3(7):660-74.


4.
The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event. Open publication in PubMed
Olsen DA, Petersen SV, Oury TD, Valnickova Z, Thøgersen IB, Kristensen T, Bowler RP, Crapo JD, Enghild JJ.
J Biol Chem. 2004 Maj 21;279(21):22152-7.


5.
Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. Open publication in PubMed
Petersen SV, Oury TD, Ostergaard L, Valnickova Z, Wegrzyn J, Thøgersen IB, Jacobsen C, Bowler RP, Fattman CL, Crapo JD, Enghild JJ.
J Biol Chem. 2004 Apr 2;279(14):13705-10.


6.
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. Open publication in PubMed
Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, Nagase H.
J Biol Chem. 2004 Mar 12;279(11):10109-19.


7.
Proteomic analysis of hyperoxia-induced responses in the human choriocarcinoma cell line JEG-3. Open publication in PubMed
Vorum H, Østergaard M, Hensechke P, Enghild JJ, Riazati M, Rice GE.
Proteomics. 2004 Mar;4(3):861-7.


8.
Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes. Open publication in PubMed
Fowlkes JL, Serra DM, Bunn RC, Thrailkill KM, Enghild JJ, Nagase H.
Endocrinology. 2004 Feb;145(2):620-6.


2003


1.
The dual nature of human extracellular superoxide dismutase: one sequence and two structures. Open publication in PubMed
Petersen SV, Oury TD, Valnickova Z, Thøgersen IB, Højrup P, Crapo JD, Enghild JJ.
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13875-80.


2.
Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide dismutase. Open publication in PubMed
Fattman CL, Chang LY, Termin TA, Petersen L, Enghild JJ, Oury TD.
Free Radic Biol Med. 2003 Okt 1;35(7):763-71.


3.
Regulation of receptor for advanced glycation end products during bleomycin-induced lung injury. Open publication in PubMed
Hanford LE, Fattman CL, Shaefer LM, Enghild JJ, Valnickova Z, Oury TD.
Am J Respir Cell Mol Biol. 2003 Sep;29 (3 Suppl):S77-81.


4.
Transforming growth factor beta induced protein accumulation in granular corneal dystrophy type III (Reis-Bücklers dystrophy). Identification by mass spectrometry in 15 year old two-dimensional protein gels. Open publication in PubMed
Hedegaard CJ, Thøgersen IB, Enghild JJ, Klintworth GK, Møller-Pedersen T.
Mol Vis. 2003 Aug 20;9:355-9.


5.
Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization Open publication in PubMed
Petersen SV, Valnickova Z, Enghild JJ.
Biochem J. 2003 Aug 15;374(Pt 1):199-206.


6.
Biochemical importance of glycosylation of plasminogen activator inhibitor-1. Open publication in PubMed
Gils A, Pedersen KE, Skottrup P, Christensen A, Naessens D, Deinum J, Enghild JJ, Declerck PJ, Andreasen PA.
Thromb Haemost. 2003 Aug;90(2):206-17.


2002


1.
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Open publication in PubMed
Bowler RP, Sheng H, Enghild JJ, Pearlstein RD, Warner DS, Crapo JD.
Free Radic Biol Med. 2002 Okt 15;33(8):1141-52.


2.
Structural and functional characterization of tissue factor pathway inhibitor following degradation by matrix metalloproteinase-8 Open publication in PubMed
Cunningham AC, Hasty KA, Enghild JJ, Mast AE.
Biochem J. 2002 Okt 15;367(Pt 2):451-8.


3.
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Open publication in PubMed
Sheng H, Enghild JJ, Bowler R, Patel M, Batini?-Haberle I, Calvi CL, Day BJ, Pearlstein RD, Crapo JD, Warner DS.
Free Radic Biol Med. 2002 Okt 1;33(7):947-61.


4.
New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. Open publication in PubMed
Thøgersen IB, Hammes SR, Rubenstein DS, Pizzo SV, Valnickova Z, Enghild JJ.
Biochim Biophys Acta. 2002 Jul 29;1598(1-2):131-9.


5.
Calbindin D28k exhibits properties characteristic of a Ca2+ sensor. Open publication in PubMed
Berggård T, Miron S, Onnerfjord P, Thulin E, Akerfeldt KS, Enghild JJ, Akke M, Linse S.
J Biol Chem. 2002 Maj 10;277(19):16662-72.


6.
Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase Open publication in PubMed
Bowler RP, Nicks M, Olsen DA, Thøgersen IB, Valnickova Z, Højrup P, Franzusoff A, Enghild JJ, Crapo JD.
J Biol Chem. 2002 Maj 10;277(19):16505-11.


2001


1.
Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment Open publication in PubMed
Fattman CL, Chu CT, Kulich SM, Enghild JJ, Oury TD.
Free Radic Biol Med. 2001 Nov 15;31(10):1198-207.


2.
Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity Open publication in PubMed
Cianciolo GJ, Enghild JJ, Pizzo SV.
Vaccine. 2001 Nov 12;20(3-4):554-62.


2000


1.
Secretion of extracellular superoxide dismutase in neonatal lungs Open publication in PubMed
Nozik-Grayck E, Dieterle CS, Piantadosi CA, Enghild JJ, Oury TD.
Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(5):L977-84.


2.
Purification and characterization of extracellular superoxide dismutase in mouse lung Open publication in PubMed
Fattman CL, Enghild JJ, Crapo JD, Schaefer LM, Valnickova Z, Oury TD.
Biochem Biophys Res Commun. 2000 Aug 28;275(2):542-8.


1999


1.
Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound Open publication in PubMed
Berggård T, Cohen A, Persson P, Lindqvist A, Cedervall T, Silow M, Thøgersen IB, Jönsson JA, Enghild JJ, Akerström B.
Protein Sci. 1999 Dec 8;(12):2611-20.


2.
Organization of the inter-alpha-inhibitor heavy chains on the chondroitin sulfate originating from Ser(10) of bikunin: posttranslational modification of IalphaI-derived bikunin Open publication in PubMed
Enghild JJ, Thøgersen IB, Cheng F, Fransson LA, Roepstorff P, Rahbek-Nielsen H.
Biochemistry. 1999 Sep 7;38(36):11804-13.


3.
Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment Open publication in PubMed
Fishman DA, Kearns A, Larsh S, Enghild JJ, Stack MS.
Biochem J. 1999 Aug 1;341 ( Pt 3):765-9.


4.
The heparin-binding domain of extracellular superoxide dismutase is proteolytically processed intracellularly during biosynthesis Open publication in PubMed
Enghild JJ, Thogersen IB, Oury TD, Valnickova Z, Hojrup P, Crapo JD.
J Biol Chem. 1999 Maj 21;274(21):14818-22.


5.
Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation Open publication in PubMed
Stack MS, Gately S, Bafetti LM, Enghild JJ, Soff GA.
Biochem J. 1999 Maj 15;340 ( Pt 1):77-84.


6.
Angiostatin binds ATP synthase on the surface of human endothelial cells Open publication in PubMed
Moser TL, Stack MS, Asplin I, Enghild JJ, Højrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV.
Proc Natl Acad Sci U S A. 1999 Mar 6;96(6):2811-6.


7.
Histologic distribution and biochemical properties of alpha 1-microglobulin in human placenta Open publication in PubMed
Berggård T, Enghild JJ, Badve S, Salafia CM, Lögdberg L, Akerström B.
Am J Reprod Immunol. 1999 Jan;41(1):52-60.



             Click here for all publications before 2000